If your Teacup Puppy is not accustomed to the car, take it for a few short rides before the trip. This can help the puppy to get used to the car and not become nervous or car sick.  

Teacup Puppies are often most comfortable in pet carriers, which can be purchased in various sizes at most pet stores. Carriers give Teacup Puppies a sense of security and familiar surroundings.   If you have a larger dog make sure that you don't let him stick his head outside of your car. 

While packing for your trip, remember to throw in a few of your  puppy's favorite toys, food and water bowls, a leash, and food. You should also carry a first aid kit for your Teacup Puppy in case of an emergency. 

Find hotels, motels, and campsites that accept animals and book them ahead of time.   Learn more about the area you will be visiting. Your veterinarian can tell you if there are any diseases like heartworm or Lyme disease and vaccinations or medications your Teacup Puppy may require. A health examination following your trip should be considered to determine if any internal parasites.

To avoid losing your Teacup Puppy  during a trip, make sure your pet is wearing an I.D. tag. To be doubly protected, consider having your pet a microchip implanted. "The more methods of identification, the better chance that the owner will be found.   

• Depending upon how far you are traveling and the individual state laws, you may need to have your Teacup puppy’s immunization records with you to show to officials to prove his shots are up to date.
• Never leave your Teacup Puppy in the car on a warm day, even with windows cracked open. Internal temperatures can climb quickly and leave your puppy in distress or worse, dead.
• Leave a window cracked open while driving, but not wide enough for the puppy to stick his head out. He could get tossed from the car or get road debris in his eyes.